Childhood Adversity and Adolescent Stress Cardiovascular Dysregulation: Moderating Role of Autonomic Nervous System Multilocus Genetic Variation

doi:10.3724/SP.J.1041.2026.1736

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HUANG Ye Fei, LÜ Wei. (2026). Childhood Adversity and Adolescent Stress Cardiovascular Dysregulation: Moderating Role of Autonomic Nervous System Multilocus Genetic Variation. Acta Psychologica Sinica, 58(9), 1736-1750.

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URL: https://journal.psych.ac.cn/acps/EN/10.3724/SP.J.1041.2026.1736

https://journal.psych.ac.cn/acps/EN/Y2026/V58/I9/1736

Figures/Tables 6

Table 1a Descriptive statistics and correlations among study variables in sample 1.

Variables	1	2	3	4	5	6	7	8	9	10	11	12
1. Gender
2. Age	?0.06
3. MGPS	?0.03	?0.03
4. Childhood adversity	?0.16^*	?0.08	?0.05
5. Emotional abuse	?0.05	?0.08	?0.01	0.83^***
6. Physical abuse	?0.15^*	?0.09	?0.02	0.72^***	0.69^***
7. Sexual abuse	?0.07	?0.09	?0.12^*	0.37^***	0.35^***	0.31^***
8. Emotional neglect	?0.14^*	?0.06	?0.03	0.85^***	0.52^***	0.39^***	0.11
9. Physical neglect	?0.20^**	?0.01	?0.07	0.82^***	0.52^***	0.43^***	0.26^***	0.72
10. HR reactivity	0.14^*	0.00	0.03	?0.08	?0.10	?0.12	0.03	?0.03	?0.07
11. SBP reactivity	0.21^***	?0.02	?0.05	?0.14^*	?0.08	?0.13^*	0.01	?0.13^*	?0.12	0.70^***
12. DBP reactivity	0.30^***	?0.13^*	?0.01	?0.18^**	?0.09	?0.13^*	0.01	?0.17^**	?0.19^**	0.63^***	0.81^***
M	?	12.95	3.11	1.63	1.61	1.30	1.07	2.51	1.67	13.30	12.33	7.03
SD	?	0.79	1.48	0.53	0.82	0.55	0.24	1.13	0.62	9.79	9.35	3.94

Table 1a Descriptive statistics and correlations among study variables in sample 1.

Variables	1	2	3	4	5	6	7	8	9	10	11	12
1. Gender
2. Age	?0.06
3. MGPS	?0.03	?0.03
4. Childhood adversity	?0.16^*	?0.08	?0.05
5. Emotional abuse	?0.05	?0.08	?0.01	0.83^***
6. Physical abuse	?0.15^*	?0.09	?0.02	0.72^***	0.69^***
7. Sexual abuse	?0.07	?0.09	?0.12^*	0.37^***	0.35^***	0.31^***
8. Emotional neglect	?0.14^*	?0.06	?0.03	0.85^***	0.52^***	0.39^***	0.11
9. Physical neglect	?0.20^**	?0.01	?0.07	0.82^***	0.52^***	0.43^***	0.26^***	0.72
10. HR reactivity	0.14^*	0.00	0.03	?0.08	?0.10	?0.12	0.03	?0.03	?0.07
11. SBP reactivity	0.21^***	?0.02	?0.05	?0.14^*	?0.08	?0.13^*	0.01	?0.13^*	?0.12	0.70^***
12. DBP reactivity	0.30^***	?0.13^*	?0.01	?0.18^**	?0.09	?0.13^*	0.01	?0.17^**	?0.19^**	0.63^***	0.81^***
M	?	12.95	3.11	1.63	1.61	1.30	1.07	2.51	1.67	13.30	12.33	7.03
SD	?	0.79	1.48	0.53	0.82	0.55	0.24	1.13	0.62	9.79	9.35	3.94

Table 1b Descriptive statistics and correlations among study variables in sample 2.

Variables	1	2	3	4	5	6	7	8	9	10	11	12
1. Gender
2. Age	?0.08
3. MGPS	?0.01	0.09
4. Childhood adversity	0.04	0.16^**	?0.03
5. Emotional abuse	0.11^*	0.16^**	?0.01	0.78^***
6. Physical abuse	?0.05	0.14^**	?0.06	0.65^***	0.52^***
7. Sexual abuse	?0.13^*	0.13^*	0.03	0.42^***	0.25^***	0.47^***
8. Emotional neglect	0.05	0.09	?0.04	0.85^***	0.49^***	0.34^***	0.16^**
9. Physical neglect	0.02	0.10	0.01	0.81^***	0.49^***	0.41^***	0.23^***	0.66
10. HR reactivity	0.05	?0.09	0.02	?0.13^*	?0.08	?0.12^*	?0.07	?0.11^*	?0.10
11. SBP reactivity	0.00	?0.08	?0.02	?0.15^**	?0.08	?0.13^*	?0.11^*	?0.14^*	?0.11^*	0.63^***
12. DBP reactivity	0.01	?0.15^**	?0.04	?0.09	?0.06	?0.12^*	?0.10	?0.05	?0.05	0.57^***	0.82^***
M	?	12.98	3.12	1.66	1.62	1.24	1.09	2.54	1.81	6.15	6.76	4.38
SD	?	0.74	1.37	0.47	0.74	0.41	0.29	1.04	0.62	5.60	7.05	3.76

Table 1b Descriptive statistics and correlations among study variables in sample 2.

Variables	1	2	3	4	5	6	7	8	9	10	11	12
1. Gender
2. Age	?0.08
3. MGPS	?0.01	0.09
4. Childhood adversity	0.04	0.16^**	?0.03
5. Emotional abuse	0.11^*	0.16^**	?0.01	0.78^***
6. Physical abuse	?0.05	0.14^**	?0.06	0.65^***	0.52^***
7. Sexual abuse	?0.13^*	0.13^*	0.03	0.42^***	0.25^***	0.47^***
8. Emotional neglect	0.05	0.09	?0.04	0.85^***	0.49^***	0.34^***	0.16^**
9. Physical neglect	0.02	0.10	0.01	0.81^***	0.49^***	0.41^***	0.23^***	0.66
10. HR reactivity	0.05	?0.09	0.02	?0.13^*	?0.08	?0.12^*	?0.07	?0.11^*	?0.10
11. SBP reactivity	0.00	?0.08	?0.02	?0.15^**	?0.08	?0.13^*	?0.11^*	?0.14^*	?0.11^*	0.63^***
12. DBP reactivity	0.01	?0.15^**	?0.04	?0.09	?0.06	?0.12^*	?0.10	?0.05	?0.05	0.57^***	0.82^***
M	?	12.98	3.12	1.66	1.62	1.24	1.09	2.54	1.81	6.15	6.76	4.38
SD	?	0.74	1.37	0.47	0.74	0.41	0.29	1.04	0.62	5.60	7.05	3.76

Table 2a Effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 1.

Variable	HR reactivity						SBP reactivity						DBP reactivity
Variable	β	SE	t	p	q	R²	β	SE	t	p	q	R²	β	SE	t	p	q	R²
Step 1						0.02						0.04						0.10
Gender	0.14	0.06	2.29	0.023	0.046		0.21	0.06	3.35	0.001	0.002		0.29	0.06	4.85	<0.001	<0.001
Age	0.01	0.06	0.21	0.837	0.837		?0.01	0.06	?0.16	0.872	0.872		?0.11	0.06	?1.92	0.056	0.056
Step 2						0.03						0.06						0.12
Gender	0.13	0.06	2.11	0.036	0.144		0.19	0.06	2.99	0.003	0.012		0.27	0.06	4.40	<0.001	<0.001
Age	0.01	0.06	0.14	0.892	0.892		?0.02	0.06	?0.35	0.730	0.730		?0.13	0.06	?2.14	0.033	0.044
Childhood adversity	?0.06	0.06	?0.95	0.341	0.682		?0.11	0.06	?1.80	0.072	0.144		?0.14	0.06	?2.38	0.018	0.036
MGPS	0.04	0.06	0.55	0.580	0.773		?0.05	0.06	?0.87	0.388	0.517		?0.02	0.06	?0.26	0.795	0.795
Step 3						0.06						0.09						0.15
Gender	0.12	0.06	1.95	0.052	0.130		0.18	0.06	2.84^**	0.005	0.013		0.26	0.06	4.28^***	<0.001	<0.001
Age	0.01	0.06	0.12	0.907	0.907		?0.02	0.06	?0.37	0.710	0.710		?0.13	0.06	?2.19^*	0.030	0.038
Childhood adversity	?0.07	0.06	?1.09	0.276	0.460		?0.12	0.06	?1.95	0.052	0.087		?0.15	0.06	?2.53^*	0.012	0.020
MGPS	0.06	0.06	0.92	0.357	0.446		?0.03	0.06	?0.51	0.613	0.766		0.01	0.06	0.09	0.931	0.931
Childhood adversity × MGPS	?0.15	0.05	?2.91^**	0.004	0.020		?0.15	0.05	?2.90^**	0.004	0.020		?0.14	0.05	?2.77^**	0.006	0.015

Table 2a Effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 1.

Variable	HR reactivity						SBP reactivity						DBP reactivity
Variable	β	SE	t	p	q	R²	β	SE	t	p	q	R²	β	SE	t	p	q	R²
Step 1						0.02						0.04						0.10
Gender	0.14	0.06	2.29	0.023	0.046		0.21	0.06	3.35	0.001	0.002		0.29	0.06	4.85	<0.001	<0.001
Age	0.01	0.06	0.21	0.837	0.837		?0.01	0.06	?0.16	0.872	0.872		?0.11	0.06	?1.92	0.056	0.056
Step 2						0.03						0.06						0.12
Gender	0.13	0.06	2.11	0.036	0.144		0.19	0.06	2.99	0.003	0.012		0.27	0.06	4.40	<0.001	<0.001
Age	0.01	0.06	0.14	0.892	0.892		?0.02	0.06	?0.35	0.730	0.730		?0.13	0.06	?2.14	0.033	0.044
Childhood adversity	?0.06	0.06	?0.95	0.341	0.682		?0.11	0.06	?1.80	0.072	0.144		?0.14	0.06	?2.38	0.018	0.036
MGPS	0.04	0.06	0.55	0.580	0.773		?0.05	0.06	?0.87	0.388	0.517		?0.02	0.06	?0.26	0.795	0.795
Step 3						0.06						0.09						0.15
Gender	0.12	0.06	1.95	0.052	0.130		0.18	0.06	2.84^**	0.005	0.013		0.26	0.06	4.28^***	<0.001	<0.001
Age	0.01	0.06	0.12	0.907	0.907		?0.02	0.06	?0.37	0.710	0.710		?0.13	0.06	?2.19^*	0.030	0.038
Childhood adversity	?0.07	0.06	?1.09	0.276	0.460		?0.12	0.06	?1.95	0.052	0.087		?0.15	0.06	?2.53^*	0.012	0.020
MGPS	0.06	0.06	0.92	0.357	0.446		?0.03	0.06	?0.51	0.613	0.766		0.01	0.06	0.09	0.931	0.931
Childhood adversity × MGPS	?0.15	0.05	?2.91^**	0.004	0.020		?0.15	0.05	?2.90^**	0.004	0.020		?0.14	0.05	?2.77^**	0.006	0.015

Table 2b Effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 2.

Variable	HR reactivity						SBP reactivity						DBP reactivity
Variable	β	SE	t	p	q	R²	β	SE	t	p	q	R²	β	SE	t	p	q	R²
Step 1						0.01						0.01						0.02
Gender	0.04	0.05	0.77	0.442	0.442		?0.01	0.05	?0.15	0.881	0.881		?0.01	0.05	?0.15	0.883	0.883
Age	?0.08	0.05	?1.58	0.115	0.230		?0.08	0.05	?1.54	0.124	0.248		?0.15	0.05	?2.89	0.004	0.008
Step 2						0.02						0.03						0.03
Gender	0.05	0.05	0.89	0.376	0.501		0.00	0.05	?0.01	0.989	0.989		0.00	0.05	?0.08	0.936	0.936
Age	?0.07	0.05	?1.24	0.215	0.430		?0.06	0.05	?1.08	0.281	0.562		?0.14	0.05	?2.59	0.010	0.040
Childhood adversity	?0.12	0.05	?2.21	0.028	0.112		?0.14	0.05	?2.62	0.009	0.036		?0.07	0.05	?1.25	0.212	0.424
MGPS	0.02	0.05	0.41	0.681	0.681		?0.02	0.05	?0.31	0.760	1.000		?0.03	0.05	?0.61	0.540	0.720
Step 3						0.05						0.05						0.03
Gender	0.05	0.05	1.03	0.303	0.379		0.01	0.05	0.12	0.901	0.901		0.00	0.05	?0.02	0.986	0.986
Age	?0.08	0.05	?1.47	0.142	0.237		?0.07	0.05	?1.13	0.190	0.317		?0.14	0.05	?2.69^**	0.008	0.040
Childhood adversity	?0.12	0.05	?2.25^*	0.025	0.063		?0.14	0.05	?2.68^**	0.008	0.020		?0.07	0.05	?1.26	0.209	0.348
MGPS	0.02	0.05	0.40	0.688	0.688		?0.02	0.05	?0.32	0.747	0.934		?0.03	0.05	?0.62	0.535	0.669
Childhood adversity × MGPS	?0.15	0.05	?3.07^**	0.002	0.010		?0.15	0.05	?3.12^**	0.002	0.010		?0.07	0.05	?1.44	0.151	0.378

Table 2b Effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 2.

Variable	HR reactivity						SBP reactivity						DBP reactivity
Variable	β	SE	t	p	q	R²	β	SE	t	p	q	R²	β	SE	t	p	q	R²
Step 1						0.01						0.01						0.02
Gender	0.04	0.05	0.77	0.442	0.442		?0.01	0.05	?0.15	0.881	0.881		?0.01	0.05	?0.15	0.883	0.883
Age	?0.08	0.05	?1.58	0.115	0.230		?0.08	0.05	?1.54	0.124	0.248		?0.15	0.05	?2.89	0.004	0.008
Step 2						0.02						0.03						0.03
Gender	0.05	0.05	0.89	0.376	0.501		0.00	0.05	?0.01	0.989	0.989		0.00	0.05	?0.08	0.936	0.936
Age	?0.07	0.05	?1.24	0.215	0.430		?0.06	0.05	?1.08	0.281	0.562		?0.14	0.05	?2.59	0.010	0.040
Childhood adversity	?0.12	0.05	?2.21	0.028	0.112		?0.14	0.05	?2.62	0.009	0.036		?0.07	0.05	?1.25	0.212	0.424
MGPS	0.02	0.05	0.41	0.681	0.681		?0.02	0.05	?0.31	0.760	1.000		?0.03	0.05	?0.61	0.540	0.720
Step 3						0.05						0.05						0.03
Gender	0.05	0.05	1.03	0.303	0.379		0.01	0.05	0.12	0.901	0.901		0.00	0.05	?0.02	0.986	0.986
Age	?0.08	0.05	?1.47	0.142	0.237		?0.07	0.05	?1.13	0.190	0.317		?0.14	0.05	?2.69^**	0.008	0.040
Childhood adversity	?0.12	0.05	?2.25^*	0.025	0.063		?0.14	0.05	?2.68^**	0.008	0.020		?0.07	0.05	?1.26	0.209	0.348
MGPS	0.02	0.05	0.40	0.688	0.688		?0.02	0.05	?0.32	0.747	0.934		?0.03	0.05	?0.62	0.535	0.669
Childhood adversity × MGPS	?0.15	0.05	?3.07^**	0.002	0.010		?0.15	0.05	?3.12^**	0.002	0.010		?0.07	0.05	?1.44	0.151	0.378

Figure 1a. Interaction effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 1.

Figure 1a. Interaction effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 1.

Figure 1b. Interaction effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 2.

Figure 1b. Interaction effect of childhood adversity and MGPS on stress cardiovascular reactivity in Sample 2.

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